New substrates of acetylcholinesterase

novel coumarin analogues: as new acetylcholinesterase inhibitors

Acetylcholinesterase: old questions and new developments

The family of cholinesterases, including acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), has been of significant interest to neuroscientists for several decades. Cholinesterases play an essential role in mediating neurotransmission in cholinergic synapses, which control the higher brain functions such as learning and memory; they also are causally involved in controlling nerve-mus...

New Acetylcholinesterase Inhibitors for Alzheimer's Disease

Acetylcholinesterase (AChE) remains a highly viable target for the symptomatic improvement in Alzheimer's disease (AD) because cholinergic deficit is a consistent and early finding in AD. The treatment approach of inhibiting peripheral AchE for myasthenia gravis had effectively proven that AchE inhibition was a reachable therapeutic target. Subsequently tacrine, donepezil, rivastigmine, and gal...

new pantacyclic tacrines as potent acetylcholinesterase inhibitors

Critical Evaluation of Acetylthiocholine Iodide and Acetylthiocholine Chloride as Substrates for Amperometric Biosensors Based on Acetylcholinesterase

Numerous amperometric biosensors have been developed for the fast analysis of neurotoxic insecticides based on inhibition of cholinesterase (AChE). The analytical signal is quantified by the oxidation of the thiocholine that is produced enzymatically by the hydrolysis of the acetylthiocholine pseudosubstrate. The pseudosubstrate is a cation and it is associated with chloride or iodide as corres...